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KMID : 0379519990150030413
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한국독성학회지
1999 Volume.15 No. 3 p.413 ~ p.417
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Mutagenecuty Test of Erythropoietin (EPO)
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Che Jeong-Hwan
Li Guang-Xun
Park Jin-Sung
Yun Jun-Won
Kim Tae-Won
Park Jie-Eun
Youn Sin-Keun
Lee Yong-Soon
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Abstract
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In order to evaluate the mutagenic potential of erythropoietin (EPO), Salmonella typhimurium reversion assay, chromosomal aberration test on chinese hamster lung cells and in vivo micronucleus assay using mouse bone marrow cells were performed. In the reverse mutation test using Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA102 did not increase the number of revertant at any of the concentration tested in this study. EPO did not increase the number of cells having structural or numerical chromosome aberration in cytogenetic test. In mouse micronucleus test, no significant increase in the occurrence of micro nucleated polychromatic erythrocytes was observed in ICR male mice intraperitoneally administered with EPO. These results indicate that EPO has no mutagenic effects under these experimental conditions.
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KEYWORD
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Salmonella typhimurium reversion assay, Chromosomal abeeration test, Micronucleus assay, Ergthropoietin
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